In the present work a series of hydrophilic and hydrophobic 1-ethyl-3-methylimidazolium room temperature ionic liquids (RTILs) have been employed to probe the wettability in nano-scale using molecular dynamics (MD) simulation. The simulation results confirm droplet size, intrinsic viscosity and simulated temperature play the dominant role in the wettability of ionic liquids (ILs) in nano-scale.